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- CD3 Antibodies
Proteintech
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Cite CD3 Monoclonal Antibody (OKT3), CoraLite® Plus 750
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CD3 Antibody (CL750-65133) in Flow
1X10^6 human PBMCs were surface co-stained with FITC Anti-Human CD19 and 5 µL CoraLite® Plus 750 Anti-Human CD3 (CL750-65133, Clone:OKT3) or Mouse IgG2a Isotype Control. Cells were not fixed. Lymphocytes were gated. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Product Details
CL750-65133
Applications
Tested Dilution
Publications
Flow Cytometry(Flow)
Assay-dependent
-
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
OKT3
Immunogen
The exact sequence is proprietary
Conjugate
CoraLite® Plus 750
- APC
- Atlantic Blue
- Cardinal Red
- CoraLite Plus 488
- CoraLite Plus 647
- CoraLitePlus 405
- CoraLitePlus 555
- FITC Plus
- PE
- Unconjugated
Excitation/Emission Max
755/780 nm
Form
Liquid
Purification
Affinity chromatography
Storage buffer
PBS with 0.5% BSA
Contains
0.09% sodium azide
Storage conditions
4° C, store in dark
Shipping conditions
Wet ice
Target Information
The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases:CD247; CD247 antigen, zeta subunit; CD3 antigen, delta subunit; CD3 delta; CD3 TCR complex; CD3-epsilon; CD3d; CD3d antigen, delta polypeptide (TiT3 complex); CD3d molecule, delta (CD3-TCR complex); CD3e; CD3e antigen, epsilon polypeptide (TiT3 complex); CD3e molecule, epsilon (CD3-TCR complex); CD3g; CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); CD3Z antigen, zeta polypeptide (TiT3 complex); CD3zeta chain; FLJ18683; Leu-4; OKT3, delta chain; T cell antigen receptor complex epsilon subunit of T3; T-cell antigen receptor complex, epsilon subunit of T3; T-cell antigen receptor complex, gamma subunit of T3; T-cell antigen receptor complex, zeta subunit of CD3; T-cell receptor T3 delta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex; TCR zeta chain
Gene Aliases:CD247; CD3-DELTA; CD3-GAMMA; CD3-ZETA; CD3D; CD3E; CD3G; CD3H; CD3Q; CD3Z; IMD17; IMD18; IMD19; IMD25; T3D; T3E; T3G; T3Z; TCRE; TCRZ
Entrez Gene ID:(Human) 919, (Human) 915, (Human) 916, (Human) 917
Molecular Function: 
defense/immunity protein immunoglobulin receptor superfamily
Function(s)
viral processT cell costimulationFc-gamma receptor signaling pathway involved in phagocytosisregulation of defense response to virus by virusregulation of immune responseT cell receptor signaling pathwaycell surface receptor signaling pathwayT cell differentiationpositive thymic T cell selectionpositive regulation of transcription from RNA polymerase II promoterpositive regulation of T cell anergyprotein complex assemblytransmembrane receptor protein tyrosine kinase signaling pathwaysignal complex assemblyG-protein coupled receptor signaling pathwayresponse to nutrientpositive regulation of gene expressionnegative regulation of gene expressionpositive regulation of interferon-gamma productionpositive regulation of interleukin-4 productionpositive regulation of T cell proliferationT cell activationregulation of apoptotic processnegative thymic T cell selectionpositive regulation of interleukin-2 biosynthetic processnegative regulation of smoothened signaling pathwaypositive regulation of alpha-beta T cell proliferationpositive regulation of peptidyl-tyrosine phosphorylationpositive regulation of calcium-mediated signalingapoptotic signaling pathwayestablishment or maintenance of cell polarityprotein transportregulation of lymphocyte apoptotic process
Process(es)
transmembrane signaling receptor activityprotein bindingidentical protein bindingprotein hom*odimerization activitytranscription coactivator activityprotein heterodimerization activityreceptor signaling protein activitySH3 domain bindingprotein kinase bindingreceptor signaling complex scaffold activityT cell receptor binding
It has to be done as per old AB suggested Products section.
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