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, Nicolas Ripari Department of Chemical and Biological Sciences,Institute of Biosciences, São Paulo State University (UNESP) , Campus Botucatu, Botucatu, SP18618-691 , Brazil Search for other works by this author on: Oxford Academic Mariana da Silva Honorio Department of Chemical and Biological Sciences,Institute of Biosciences, São Paulo State University (UNESP) , Campus Botucatu, Botucatu, SP18618-691 , Brazil Search for other works by this author on: Oxford Academic Arthur Alves Sartori Department of Chemical and Biological Sciences,Institute of Biosciences, São Paulo State University (UNESP) , Campus Botucatu, Botucatu, SP18618-691 , Brazil Search for other works by this author on: Oxford Academic Larissa Ragozo Cardoso de Oliveira Department of Chemical and Biological Sciences,Institute of Biosciences, São Paulo State University (UNESP) , Campus Botucatu, Botucatu, SP18618-691 , Brazil Search for other works by this author on: Oxford Academic Jairo Kenupp Bastos Department of Pharmaceutical Sciences,School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo (USP) , Ribeirão Preto, SP14040-903 , Brazil Search for other works by this author on: Oxford Academic José Maurício Sforcin Department of Chemical and Biological Sciences,Institute of Biosciences, São Paulo State University (UNESP) , Campus Botucatu, Botucatu, SP18618-691 , Brazil Corresponding author. Department of Chemical and Biological Sciences,Institute of Biosciences,São Paulo State University (UNESP), Campus Botucatu,Botucatu, SP18618-691,Brazil. E-mail: jose.m.sforcin@unesp.br Search for other works by this author on: Oxford Academic
Journal of Pharmacy and Pharmacology, rgae135, https://doi.org/10.1093/jpp/rgae135
Published:
25 October 2024
Article history
Received:
28 May 2024
Accepted:
07 October 2024
Published:
25 October 2024
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Nicolas Ripari, Mariana da Silva Honorio, Arthur Alves Sartori, Larissa Ragozo Cardoso de Oliveira, Jairo Kenupp Bastos, José Maurício Sforcin, Brazilian red propolis synergistically with imipenem modulates immunological parameters and the bactericidal activity of human monocytes against methicillin-resistant Staphylococcus aureus (MRSA), Journal of Pharmacy and Pharmacology, 2024;, rgae135, https://doi.org/10.1093/jpp/rgae135
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Abstract
Objectives
Propolis is a bee product found all over the globe and has a well-known antibacterial activity. Previous findings of our group revealed that the combination of Brazilian red propolis (BRP) with a lower concentration of imipenem (IPM) exerted a bactericidal action against methicillin-resistant Staphylococcus aureus (MRSA) in vitro. Here, we aimed at investigating the effects of BRP in combination or not with IPM on human monocytes to assess a possible immunomodulatory action.
Methods
Monocyte metabolic activity was analysed by MTT assay, cytokine production (TNF-α, IL-1β, IL-6, IL-8, and IL-10) by ELISA, and the expression of cell markers (TLR-2, TLR-4, HLA-DR, and CD80) by flow cytometry. The bactericidal activity of monocytes over MRSA was determined by colony-forming units’ count.
Key findings
BRP alone or in combination with IPM exerted no cytotoxic effects on monocytes. BRP downregulated TLR-2 expression and inhibited TNF-α, IL-1β, and IL-6 production, while BRP + IPM stimulated these parameters. BPR alone or in combination increased the bactericidal activity similarly to LPS-activated monocytes.
Conclusions
Data indicated the potential of BRP as an anti-inflammatory agent increasing the bactericidal activity of monocytes against MRSA. The combination of BRP + IPM exhibited a stimulatory profile that may be potentially useful in treating patients with MRSA infection.
propolis, monocyte, Toll-like receptor, cytokine, methicillin-resistant Staphylococcus aureus
© The Author(s) 2024. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/pages/standard-publication-reuse-rights)
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